Abstract Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-
related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct …

Interleukin-1 receptor family members (ILRs) and Toll-Like Receptors (TLRs) play pivotal
role in immunity and inflammation and are expressed by most cell types including cells of …

Using a mouse model in which tumors show a growth-regression-recurrence pattern, we
investigated the mechanisms for down-regulation of cytotoxic T lymphocyte–mediated tumor …

Cytokines are important in the regulation of haematopoiesis and immune responses, and
can influence lymphocyte development. Here we have identified a class I cytokine receptor …

Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian
tissues,. Although ILC2s are found in cancers of these tissues, their roles in cancer immunity …

We report here the identification of a ligand-receptor system that, upon engagement, leads
to the establishment of an antiviral state. Three closely positioned genes on human …

Abstract Toll-like receptors (TLRs), which recognize pathogen-associated molecular
patterns, and members of the pro-inflammatory interleukin-1 receptor (IL-1R) family, share …

Natural killer (NK) cells are critical for both innate and adaptive immunity,. The development
of NK cells requires interactions between their progenitors and the bone-marrow …

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …

The type-I interferon (IFN-α/β) response is critical to immunity against viruses and can be
triggered in many cell types by cytosolic detection of viral infection, or in differentiated …