Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA
damage response is usually just regarded as an apoptotic trigger. However, growing …

Over the past decade, evidence has emerged suggesting a broader role for cytochrome c
(Cyt c) in programmed cell death. Recently, we demonstrated the ability of Cyt c to inhibit the …

Cytochrome c (Cc) is a protein that functions as an electron carrier in the mitochondrial
respiratory chain. However, Cc has moonlighting roles outside mitochondria driving the …

Background Extensive DNA damage leads to apoptosis. Histones play a central role in DNA
damage sensing and may mediate signals of genotoxic damage to cytosolic effectors …

In eukaryotes, the packaging of DNA into chromatin is essential for cell viability. Several
important DNA metabolic events require the transient disruption of chromatin structure, but …

Histone H1.2 as a trigger for apoptosis | Nature Structural & Molecular Biology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Histone chaperones can be broadly defined as histone-binding proteins that influence
chromatin dynamics in an ATP-independent manner. Their existence reflects the importance …

Maintenance of protein folding homeostasis, or proteostasis is critical for cell survival as well
as for execution of cell type specific biological processes such as muscle cell contractility …

Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA
replication, transcription, repair, and recombination. The extensive interactions between the …

The eukaryotic genome is packaged into chromatin. The nucleosome, the basic unit of
chromatin, is composed of DNA coiled around a histone octamer. Histones are among the …