Mood disorders account for a significant global disease burden, and pharmacological
innovation is needed as existing medications are suboptimal. A wide range of evidence …

The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …

Bipolar disorder (BD) is a mood disorder with genetic and neurobiological underpinnings,
characterized primarily by recurrent episodes of mania and depression, with notable …

Disruption of circadian clocks is strongly associated with mood disorders. Chronotherapies
targeting circadian rhythms have been shown to be very effective treatments of mood …

The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

Circadian rhythms regulate many biological processes and play fundamental roles in
behavior, physiology, and metabolism. Such periodicity is critical for homeostasis because …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Daily rhythms in behavior, physiology, and metabolism are an integral part of homeostasis.
These rhythms emerge from interactions between endogenous circadian clocks and …

Altered behavioral rhythms are a fundamental diagnostic feature of mood disorders. Patients
report worse subjective sleep and objective measures confirm this, implicating a role for …

There are two main reasons for the growing interest in the dependence of mood disorders
on the circadian clock and its connected pathways. First, the successful translation of …