In this study, we explore the dynamic process of colorectal cancer progression, emphasizing
the evolution toward a more metastatic phenotype. The term" evolution" as used in this study …

Colorectal cancer is one of the most malignant cancers worldwide, and efforts have been
made to elucidate the mechanism of colorectal carcinogenesis. Cellular senescence is a …

Background and Aims The initiation of cellular senescence in response to protumorigenic
stimuli counteracts malignant progression in (pre) malignant cells. Besides arresting …

Cellular senescence has been listed as a hallmark of cancer, but its role in colorectal cancer
(CRC) remains unclear. We comprehensively evaluated the transcriptome, genome, digital …

Hepatic metastasis is a clinical challenge for colorectal cancer (CRC). Senescent cancer
cells accumulate in CRC favoring tumor dissemination. Whether this mechanism progresses …

Gastrointestinal (GI) cancer includes a variety of cancers with high incidence that seriously
threaten the lives of people worldwide. Although treatment strategies continue to improve …

Colorectal cancer (CRC) is the second leading cause of death among cancer patients in the
Northern countries. CRC can reappear a long time after treatment. Recent clinical studies …

Cellular senescence can either support or inhibit cancer progression. Here, it is shown that
intratumoral infiltration of CD8+ T cells is negatively associated with the proportion of …

Over the past few decades, cellular senescence has been identified in cancer patients
undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by …

Cellular senescence is a biologically irreversible state of cell-growth arrest that occurs
following either a replicative or an oncogenic stimulus. This phenomenon occurs as a …