Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties
In the current medical era, the utilization of a single small molecule to simultaneously target
two distinct molecular targets is emerging as a highly effective strategy in the battle against …
two distinct molecular targets is emerging as a highly effective strategy in the battle against …
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and …
Herein we describe the design and synthesis of two series of sulfonamides featuring N-
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards …
Three series of indolinone-based sulfonamides (3a–f, 6a–f and 9a–f) were in vitro evaluated
as inhibitors of the tumor-associated carbonic anhydrase (CA, EC 4.2. 1.1) isoforms hCA IX …
as inhibitors of the tumor-associated carbonic anhydrase (CA, EC 4.2. 1.1) isoforms hCA IX …
Development of novel quinoline-based sulfonamides as selective cancer-associated carbonic anhydrase isoform IX inhibitors
A new series of quinoline-based benzenesulfonamides (QBS) were developed as potential
carbonic anhydrase inhibitors (CAIs). The target QBS CAIs is based on the 4 …
carbonic anhydrase inhibitors (CAIs). The target QBS CAIs is based on the 4 …
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted …
Herein we report the design and synthesis of novel N-substituted isatins-SLC-0111 hybrids
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …
Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII
Ö Güzel-Akdemir, A Akdemir, N Karalı… - Organic & biomolecular …, 2015 - pubs.rsc.org
A series of 2/3/4-[(2-oxo-1, 2-dihydro-3H-indol-3-ylidene) amino] benzenesulfonamides,
obtained from substituted isatins and 2-, 3-or 4-aminobenzenesulfonamide, showed low …
obtained from substituted isatins and 2-, 3-or 4-aminobenzenesulfonamide, showed low …
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation
The natural product piperine, the major bioactive alkaloid present in black pepper fruits, has
the ability to modulate the functional activity of several biological targets. In this study, we …
the ability to modulate the functional activity of several biological targets. In this study, we …
Discovery of novel hydroxyimine-tethered benzenesulfonamides as potential human carbonic anhydrase IX/XII inhibitors
MN Peerzada, D Vullo, N Paoletti… - ACS Medicinal …, 2023 - ACS Publications
To discover novel carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors for cancer treatment, a
series of 4-{4-[(hydroxyimino) methyl] piperazin-1-yl} benzenesulfonamides were designed …
series of 4-{4-[(hydroxyimino) methyl] piperazin-1-yl} benzenesulfonamides were designed …
Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the …
Hypoxia, a characteristic feature of solid tumors, develops as a result of excessive cell
proliferation and rapid tumor growth exceeding the oxygen supply, and can result in …
proliferation and rapid tumor growth exceeding the oxygen supply, and can result in …