Abstract Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin
secretion, loss of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet …

The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in β cells and islet
amyloid derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin …

Type 2 diabetes is associated with progressive β-cell failure manifest as a decline in insulin
secretion and increasing hyperglycemia. A growing body of evidence suggests that β-cell …

The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …

Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

Insulin secretion from the 2,000–3,000 β-cells in an islet is a highly synchronized activity
with discharge of insulin in coordinate secretory bursts at approximately 4-min intervals …

Amyloid formation in the pancreas by islet amyloid polypeptide (IAPP) leads to β-cell death
and dysfunction, contributing to islet transplant failure and to type-2 diabetes. IAPP is stored …

Amyloid formation by the neuropancreatic hormone, islet amyloid polypeptide (IAPP or
amylin), one of the most amyloidogenic sequences known, leads to islet amyloidosis in type …

Diabetes affects hundreds of millions of patients worldwide. Despite the advances in
understanding the disease and therapeutic options, it remains a leading cause of death and …

Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein
component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide …