Background Platinum based agents—cisplatin and carboplatin in combination with taxanes
are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC …

Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based
chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage …

Background Ovarian cancer (OC) is the most lethal malignant gynecological tumor type for
which limited therapeutic targets and drugs are available. Enhanced mitochondrial oxidative …

Ovarian cancer disseminates primarily intraperitoneally. Detached tumor cell aggregates
(spheroids) from the primary tumor are regarded as 'metastatic units' that exhibit a low …

We investigated the metabolic profile of cancer stem cells (CSC) isolated from patients with
epithelial ovarian cancer. CSC overexpressed genes associated with glucose uptake …

High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here, we
unravel an unanticipated metabolic heterogeneity in HGSOC. By combining proteomic …

Simple Summary Drug therapy is an important treatment for cancer patients; however, drug
resistance severely affects the survival time and quality of life of cancer patients. Oxidative …

Increasing evidence suggests that tumor development requires not only oncogene/tumor
suppressor mutations to drive the growth, survival, and metastasis but also metabolic …

Epithelial ovarian cancer (EOC) is a gynecologic malignancy with a poor prognosis due to
resistance to first-line chemotherapeutic agents. Some cancer cells are primarily dependent …

Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …