SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins
The host proteins, SERINC3 and SERINC5, have been recently shown to incorporate into
HIV-1 particles and compromise their ability to fuse with target cells, an effect that is …
HIV-1 particles and compromise their ability to fuse with target cells, an effect that is …
CD4 expression and Env conformation are critical for HIV-1 restriction by SERINC5
X Zhang, J Shi, X Qiu, Q Chai, DA Frabutt… - Journal of …, 2019 - Am Soc Microbiol
ABSTRACT Serine incorporator 5 (SERINC5) is a recently identified restriction factor that
strongly blocks HIV-1 entry but is counteracted by Nef. Notably, tier 1 HIV-1 Env proteins are …
strongly blocks HIV-1 entry but is counteracted by Nef. Notably, tier 1 HIV-1 Env proteins are …
Effect of HIV-1 Env on SERINC5 antagonism
ABSTRACT SERINC5 is able to restrict HIV-1 infection by drastically impairing the infectivity
of viral particles. Studies have shown that the HIV-1 Nef protein counters SERINC5 through …
of viral particles. Studies have shown that the HIV-1 Nef protein counters SERINC5 through …
The antagonism of HIV-1 Nef to SERINC5 particle infectivity restriction involves the counteraction of virion-associated pools of the restriction factor
B Trautz, V Pierini, R Wombacher, B Stolp… - Journal of …, 2016 - Am Soc Microbiol
ABSTRACT SERINC3 (serine incorporator 3) and SERINC5 are recently identified host cell
inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor …
inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor …
Serinc5 restricts HIV membrane fusion by altering lipid order and heterogeneity in the viral membrane
The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their
infection by an incompletely understood mechanism. We have previously reported that …
infection by an incompletely understood mechanism. We have previously reported that …
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry
The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity
when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates …
when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates …
The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles
B Trautz, H Wiedemann, C Lüchtenborg… - Journal of Biological …, 2017 - ASBMB
The host-cell restriction factor SERINC5 potently suppresses the infectivity of HIV, type 1
(HIV-1) particles, and is counteracted by the viral pathogenesis factor Nef. However, the …
(HIV-1) particles, and is counteracted by the viral pathogenesis factor Nef. However, the …
[HTML][HTML] Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5
Abstract SERINC5 (S5) is a multi-span transmembrane protein that potently blocks the
infectivity of HIV-1 produced by human T-cells. The ability of S5 to restrict infectivity …
infectivity of HIV-1 produced by human T-cells. The ability of S5 to restrict infectivity …
HIV-1 Nef antagonizes SERINC5 restriction by downregulation of SERINC5 via the endosome/lysosome system
The primate lentiviral accessory protein Nef downregulates CD4 and major
histocompatibility complex class I (MHC-I) from the cell surface via independent endosomal …
histocompatibility complex class I (MHC-I) from the cell surface via independent endosomal …
HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy
To enter a cell and establish infection, HIV must first fuse its lipid envelope with the host cell
plasma membrane. Whereas the process of HIV membrane fusion can be tracked by …
plasma membrane. Whereas the process of HIV membrane fusion can be tracked by …