Aprotinin and similar protease inhibitors as drugs against influenza
OP Zhirnov, HD Klenk, PF Wright - Antiviral research, 2011 - Elsevier
Efforts to develop new antiviral chemotherapeutic approaches are focusing on compounds
that target either influenza virus replication itself or host factor (s) that are critical to influenza …
that target either influenza virus replication itself or host factor (s) that are critical to influenza …
Aprotinin, a protease inhibitor, suppresses proteolytic activation of pandemic H1N1v influenza virus
OP Zhirnov, TY Matrosovich… - Antiviral Chemistry …, 2011 - journals.sagepub.com
Background: The recent emergence of pandemic influenza virus H1N1v stresses the need
for the development of new anti-influenza drugs. Methods: Host proteases responsible for …
for the development of new anti-influenza drugs. Methods: Host proteases responsible for …
Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections
E Böttcher-Friebertshäuser, Y Lu, D Meyer, F Sielaff… - Vaccine, 2012 - Elsevier
Cleavage of the influenza virus hemagglutinin (HA) by host cell proteases is crucial for
infectivity and spread of the virus. Some years ago, we identified TMPRSS2 and HAT from …
infectivity and spread of the virus. Some years ago, we identified TMPRSS2 and HAT from …
Suppression of influenza virus replication in infected mice by protease inhibitors
OP Zhirnov, AV Ovcharenko… - Journal of General …, 1984 - microbiologyresearch.org
Administration of the protease inhibitors, ε-aminocaproic acid or aprotinins, to mice infected
with mouse-adapted influenza virus strain A/PR/8/34 (H0N1) and A/Aichi/2/68 (H3N2) …
with mouse-adapted influenza virus strain A/PR/8/34 (H0N1) and A/Aichi/2/68 (H3N2) …
Proteases essential for human influenza virus entry into cells and their inhibitors as potential therapeutic agents
H Kido, Y Okumura, H Yamada… - Current …, 2007 - ingentaconnect.com
Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Since
IVA genome does not have the processing protease for the viral membrane fusion …
IVA genome does not have the processing protease for the viral membrane fusion …
Prophylaxis and treatment of influenza virus infection
R Kandel, KL Hartshorn - BioDrugs, 2001 - Springer
Influenza virus infections remain an important cause of morbidity and mortality. Furthermore,
a recurrence of pandemic influenza remains a real possibility. There are now effective ways …
a recurrence of pandemic influenza remains a real possibility. There are now effective ways …
Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up …
H Kido, Y Okumura, H Yamada, D Mizuno, Y Higashi… - 2004 - degruyter.com
Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Entry of
this virus into cells is primarily determined by host cellular trypsin-type processing proteases …
this virus into cells is primarily determined by host cellular trypsin-type processing proteases …
[HTML][HTML] Antiviral therapies on the horizon for influenza
L Naesens, A Stevaert, E Vanderlinden - Current opinion in pharmacology, 2016 - Elsevier
Highlights•The existing influenza drugs suffer from variable efficacy and risk of
resistance.•Several new inhibitors of diverse viral targets are in clinical trials.•Broadly …
resistance.•Several new inhibitors of diverse viral targets are in clinical trials.•Broadly …
The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells
M Yamaya, Y Shimotai, Y Hatachi, NL Kalonji… - Pulmonary …, 2015 - Elsevier
Background Serine proteases act through the proteolytic cleavage of the hemagglutinin (HA)
of influenza viruses for the entry of influenza virus into cells, resulting in infection. However …
of influenza viruses for the entry of influenza virus into cells, resulting in infection. However …
Recent strategies in the search for new anti-influenza therapies
JC Wilson, MV Itzstein - Current drug targets, 2003 - ingentaconnect.com
Influenza is a highly contagious, acute upper respiratory tract disease caused by influenza
virus, a member of the Orthomyxoviridae family. The viral particles have two surface …
virus, a member of the Orthomyxoviridae family. The viral particles have two surface …