Efforts to develop new antiviral chemotherapeutic approaches are focusing on compounds
that target either influenza virus replication itself or host factor (s) that are critical to influenza …

Background: The recent emergence of pandemic influenza virus H1N1v stresses the need
for the development of new anti-influenza drugs. Methods: Host proteases responsible for …

Cleavage of the influenza virus hemagglutinin (HA) by host cell proteases is crucial for
infectivity and spread of the virus. Some years ago, we identified TMPRSS2 and HAT from …

Administration of the protease inhibitors, ε-aminocaproic acid or aprotinins, to mice infected
with mouse-adapted influenza virus strain A/PR/8/34 (H0N1) and A/Aichi/2/68 (H3N2) …

Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Since
IVA genome does not have the processing protease for the viral membrane fusion …

Influenza virus infections remain an important cause of morbidity and mortality. Furthermore,
a recurrence of pandemic influenza remains a real possibility. There are now effective ways …

Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Entry of
this virus into cells is primarily determined by host cellular trypsin-type processing proteases …

Highlights•The existing influenza drugs suffer from variable efficacy and risk of
resistance.•Several new inhibitors of diverse viral targets are in clinical trials.•Broadly …

Background Serine proteases act through the proteolytic cleavage of the hemagglutinin (HA)
of influenza viruses for the entry of influenza virus into cells, resulting in infection. However …

Influenza is a highly contagious, acute upper respiratory tract disease caused by influenza
virus, a member of the Orthomyxoviridae family. The viral particles have two surface …