1. Prologue 582. The Hodgkin–Huxley formalism for computing the action potential 592.1
The axon action potential model 592.2 Cardiac action potential models 623. Ion-channel …

Cardiac rhythms arise from electrical activity generated by precisely timed opening and
closing of ion channels in individual cardiac myocytes. These impulses spread throughout …

The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …

Ion-channel function is determined by its gating movement. Yet, molecular dynamics and
electrophysiological simulations were never combined to link molecular structure to function …

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The conduction of electrical signals through cardiac tissue is essential for maintaining the
function of the heart, and conduction abnormalities are known to potentially lead to life …

Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

Ion channels are of universal importance for all cell types and play key roles in cellular
physiology and pathology. Increased insight into their functional mechanisms is crucial to …

Advanced computational techniques and mathematical modeling have become more and
more important to the study of cardiac electrophysiology. In this review, we provide a brief …