Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

Y Huang, Z Guan, X Dai, Y Shen, Q Wei, L Ren… - Nature …, 2021 - nature.com
Patients with primary and bone metastatic breast cancer have significantly reduced survival
and life quality. Due to the poor drug delivery efficiency of anti-metastasis therapy and the …

Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@ manganese dioxide to inhibit tumor growth and metastases

R Liang, L Liu, H He, Z Chen, Z Han, Z Luo, Z Wu… - Biomaterials, 2018 - Elsevier
Metastatic triple-negative breast cancer (mTNBC) is an aggressive disease among women
worldwide, characterized by high mortality and poor prognosis despite systemic therapy with …

Controllable hypoxia-activated chemotherapy as a dual enhancer for synergistic cancer photodynamic immunotherapy

M Wang, M He, M Zhang, S Xue, T Xu, Y Zhao, D Li… - Biomaterials, 2023 - Elsevier
The efficacy of photodynamic therapy (PDT) is severely limited by the hypoxic tumor
microenvironment (TME), while the performance of PDT-aroused antitumor immunity is …

NIR-triggered sequentially responsive nanocarriers amplified cascade synergistic effect of chemo-photodynamic therapy with inspired antitumor immunity

F Jin, J Qi, M Zhu, D Liu, Y You, G Shu… - … applied materials & …, 2020 - ACS Publications
A desirable cancer therapeutic strategy is supposed to have effective ability to not only exert
maximum anticancer ability but also inspire antitumor immunity for preventing tumor relapse …

A light-triggered self-reinforced nanoagent for targeted chemo-photodynamic therapy of breast cancer bone metastases via ER stress and mitochondria mediated …

Y Huang, Z Xiao, Z Guan, Y Shen, Y Jiang, X Xu… - Journal of Controlled …, 2020 - Elsevier
Current therapeutic strategies for the treatment of bone metastases are often limited by the
lack of selectivity, severe systemic toxicity and suboptimal efficacy. Nanomedicine meditated …

Engineering a photosensitizer nanoplatform for amplified photodynamic immunotherapy via tumor microenvironment modulation

Y Zhou, X Ren, Z Hou, N Wang, Y Jiang, Y Luan - Nanoscale horizons, 2021 - pubs.rsc.org
Photosensitizer-based photodynamic therapy (PDT) can not only kill tumor cells by the
generated cytotoxic reactive oxygen species (ROS), but also trigger immunogenic cell death …

Bioinspired hybrid protein oxygen nanocarrier amplified photodynamic therapy for eliciting anti-tumor immunity and abscopal effect

Z Chen, L Liu, R Liang, Z Luo, H He, Z Wu, H Tian… - Acs Nano, 2018 - ACS Publications
An ideal cancer therapeutic strategy is expected to possess potent ability to not only ablate
primary tumors but also prevent distance metastasis and relapse. In this study, human serum …

Upconverting Nanoparticles with a Mesoporous TiO2 Shell for Near‐Infrared‐Triggered Drug Delivery and Synergistic Targeted Cancer Therapy

M Yin, E Ju, Z Chen, Z Li, J Ren… - Chemistry–A European …, 2014 - Wiley Online Library
Malignant tumors remain a major health burden throughout the world and effective
therapeutic strategies are urgently needed. Herein, we report the synthesis of upconverting …

Light-Enhanced O2-Evolving Nanoparticles Boost Photodynamic Therapy To Elicit Antitumor Immunity

T Wang, H Zhang, Y Han, H Liu, F Ren… - … applied materials & …, 2019 - ACS Publications
Breast cancer remains to show high mortality and poor prognosis in women despite of
significant progress in recent diagnosis and treatment. Herein, we report the rational design …

Light-triggered multifunctional nanoplatform for efficient cancer photo-immunotherapy

J Yue, Q Mei, P Wang, P Miao, WF Dong… - Journal of …, 2022 - Springer
Cancer immunotherapy is limited by the immune escape of tumor cells and adverse effects.
Photo-immunotherapy, the combination of immunotherapy and phototherapy (such as …