Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin
Abstract Characterization of the progression of cellular states during human embryogenesis
can provide insights into the origin of pediatric diseases. We examined the transcriptional …
can provide insights into the origin of pediatric diseases. We examined the transcriptional …
Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
K De Preter, J Vandesompele, P Heimann, N Yigit… - Genome biology, 2006 - Springer
Background Neuroblastoma tumor cells are assumed to originate from primitive neuroblasts
giving rise to the sympathetic nervous system. Because these precursor cells are not …
giving rise to the sympathetic nervous system. Because these precursor cells are not …
Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
OC Bedoya-Reina, W Li, M Arceo, M Plescher… - Nature …, 2021 - nature.com
Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …
of the most important prognostic factors, with children less than 1 year old having favorable …
Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype
ES Hanemaaijer, T Margaritis… - Proceedings of the …, 2021 - National Acad Sciences
Neuroblastoma is the most common extracranial solid tumor and accounts for∼ 10% of
pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is …
pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is …
Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
Neuroblastoma is a childhood cancer that resembles developmental stages of the neural
crest. It is not established what developmental processes neuroblastoma cancer cells …
crest. It is not established what developmental processes neuroblastoma cancer cells …
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries
Neuroblastoma is a tumor of the peripheral sympathetic nervous system, derived from
multipotent neural crest cells (NCCs). To define core regulatory circuitries (CRCs) controlling …
multipotent neural crest cells (NCCs). To define core regulatory circuitries (CRCs) controlling …
A human cell atlas of fetal gene expression
INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
Molecular design of hypothalamus development
A wealth of specialized neuroendocrine command systems intercalated within the
hypothalamus control the most fundamental physiological needs in vertebrates …
hypothalamus control the most fundamental physiological needs in vertebrates …
Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
INTRODUCTION Circulating adrenaline can have profound effects on the body's “inner
world,” adjusting levels depending on demand to maintain organ and bodily homeostasis …
world,” adjusting levels depending on demand to maintain organ and bodily homeostasis …
Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development
S Zhang, Y Cui, X Ma, J Yong, L Yan, M Yang… - Nature …, 2020 - nature.com
The anterior pituitary gland plays a central role in regulating various physiological
processes, including body growth, reproduction, metabolism and stress response. Here, we …
processes, including body growth, reproduction, metabolism and stress response. Here, we …