B cells have a critical role in the initiation and acceleration of autoimmune diseases,
especially those mediated by autoantibodies. In the peripheral lymphoid system, mature B …

B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although previous
studies have shown many genetic polymorphisms associated with B-cell activation in …

B lymphocytes are generally recognized as the essential component of humoral immunity
and also a regulator of innate immunity. The development of B cells is precisely regulated by …

Epigenetic modifications, such as histone post-translational modifications, DNA methylation,
and alteration of gene expression by non-coding RNAs, including microRNAs (miRNAs) and …

Epigenetic marks, such as DNA methylation, histone post-translational modifications and
miRNAs, are induced in B cells by the same stimuli that drive the antibody response. They …

The humoral immune response requires coordination of molecular programs to mediate
differentiation into unique B cell subsets that help clear the infection and form immune …

In recent years, epigenetic mechanisms became widely known due to their ability to regulate
and maintain physiological processes such as cell growth, development, differentiation and …

Epigenetic events play a central role in the priming, differentiation and subset determination
of T lymphocytes. Through their influence on chromatin conformation and DNA-accessibility …

A tightly synchronized and spatial-temporal interaction among regulatory proteins within
genomic DNA and chromatin is essential for cellular commitment and differentiation. During …

Autoimmune diseases are usually complex and multifactorial, characterized by aberrant
production of autoreactive immune cells and/or autoantibodies against healthy cells and …