The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

The discovery that nitric oxide (NO) reacts with Superoxide (O2−) forming peroxynitrite
(ONOO−)(1) and the proof that this reaction occurs in vivo (2, 3) holds enormous implications …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Oxygen-derived free radicals and related oxidants are ubiquitous and short-lived
intermediates formed in aerobic organisms throughout life. These reactive species …

Nitric oxide participates in a wide array of physiological processes, ranging from
neurotransmission to precursor of cytotoxic effector molecules of the immune system …

Peroxynitrite promotes oxidative damage and is implicated in the pathophysiology of various
diseases that involve accelerated rates of nitric oxide and superoxide formation. The …

Nitric oxide and superoxide, which are produced by several cell types, rapidly combine to
form peroxynitrite. This reaction can result in nitric oxide scavenging, and thus mitigation of …

The roles of superoxide (O2•−), peroxynitrite, and carbon dioxide in the oxidative chemistry
of nitric oxide (NO) are reviewed. The formation of peroxynitrite from NO and O2•− is …

Publisher Summary This chapter examines a number of reaction pathways for nitric oxide,
with the emphasis on assessing their biological relevance. Till date, the fastest reaction for …

Modern molecular biology has revealed vast numbers of large and complex proteins and
genes that regulate body function. By contrast, discoveries over the past ten years indicate …