During acute infections, a small population of effector CD8+ T cells evades terminal
differentiation and survives as long-lived memory T cells. We demonstrate that the …

The transcription factor Blimp-1 regulates the overall accumulation of virus-specific CD8+ T
cells during acute viral infections. We found that increased proliferation and survival of Blimp …

In response to viral infection, naive CD8+ T cells proliferate and differentiate into cytotoxic
and cytokine-producing effector cells. Here we showed that the transcription factor Blimp-1 …

T cell exhaustion is common during chronic infections and can prevent optimal immunity.
Although recent studies have demonstrated the importance of inhibitory receptors and other …

B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the
development and function of antibody-producing B cells. Given that its function in T …

Tissue-resident memory CD8+ T (TRM) cells that develop in the epithelia at portals of
pathogen entry are important for improved protection against re-infection. CD8+ TRM cells …

B-lymphocyte-induced maturation protein-1 (Blimp1), is an evolutionarily conserved
transcriptional regulator originally described as a repressor of gene transcription. Blimp1 …

T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells
resulting from lack of regulatory T cells or an inability to shut down immune responses can …

B lymphocyte–induced maturation protein-1 (Blimp-1), discovered 16 years ago as a
transcriptional repressor of the IFNβ promoter, plays fundamentally important roles in many …

Blimp-1 has been identified as a key regulator of plasma cell differentiation in B cells and
effector/memory function in T cells. We demonstrate that Blimp-1 in dendritic cells (DCs) is …