Engineering mesenchymal stem cells for regenerative medicine and drug delivery

JS Park, S Suryaprakash, YH Lao, KW Leong - Methods, 2015 - Elsevier
Researchers have applied mesenchymal stem cells (MSC) to a variety of therapeutic
scenarios by harnessing their multipotent, regenerative, and immunosuppressive properties …

Optimizing mesenchymal stem cell-based therapeutics

J Wagner, T Kean, R Young, JE Dennis… - Current opinion in …, 2009 - Elsevier
Mesenchymal stem cell (MSC)-based therapeutics are showing significant benefit in multiple
clinical trials conducted by both academic and commercial organizations, but obstacles …

Mesenchymal stem cell functionalization for enhanced therapeutic applications

D Kouroupis, C Sanjurjo-Rodriguez… - … Engineering Part B …, 2019 - liebertpub.com
To date, the therapeutic efficacy of human mesenchymal stem cells (hMSCs) has been
investigated in various clinical trials with moderate or, in some cases, inconsistent results …

Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic

HH Wu, Y Zhou, Y Tabata, JQ Gao - Journal of Controlled Release, 2019 - Elsevier
Owing to the diversity and ease of preparation of nanomaterials, the rational nanocarriers
with a rational design have become increasingly popular in medical researches. Although …

Mesenchymal stem cells beyond regenerative medicine

R Shammaa, AEH El-Kadiry, J Abusarah… - Frontiers in cell and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are competent suitors of cellular therapy due to their
therapeutic impact on tissue degeneration and immune-based pathologies. Additionally …

MSCs: delivery routes and engraftment, cell‐targeting strategies, and immune modulation

TJ Kean, P Lin, AI Caplan, JE Dennis - Stem cells international, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and
in clinical trials for multiple disease states. The differentiation, trophic, and …

Mesenchymal stem cell‐based therapy: a new paradigm in regenerative medicine

NK Satija, VK Singh, YK Verma, P Gupta… - Journal of cellular …, 2009 - Wiley Online Library
Introduction• Mesenchymal stem cells and its characteristics• Experimental/preclinical MSC‐
based studies–MSC transplantation–Genetically modified MSC‐based therapy–MSC‐based …

Mesenchymal stem cells: an emerging tool for cancer targeting and therapy

V Fritz, C Jorgensen - Current stem cell research & therapy, 2008 - ingentaconnect.com
Mesenchymal stem cells (MSCs) from post-natal bone marrow possess tremendous
potential for cell-mediated gene therapy in several disease processes, and recent reports …

Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Characterization and therapeutic applications of mesenchymal stem cells for regenerative medicine

J Wang, Z Chen, M Sun, H Xu, Y Gao, J Liu, M Li - Tissue and cell, 2020 - Elsevier
Abstract Background Mesenchymal stem cells (MSCs) are multipotent, genomic stable, self-
renewable, and culturally expandable adult stem cells. MSCs facilitate tissue development …