Assessments of dentate gyrus function: discoveries and debates

M Borzello, S Ramirez, A Treves, I Lee… - Nature Reviews …, 2023 - nature.com
There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …

Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories

T Hainmueller, M Bartos - Nature Reviews Neuroscience, 2020 - nature.com
The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

Separation or binding? Role of the dentate gyrus in hippocampal mnemonic processing

JW Lee, MW Jung - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
As a major component of the hippocampal trisynaptic circuit, the dentate gyrus (DG) relays
inputs from the entorhinal cortex to the CA3 subregion. Although the anatomy of the DG is …

What is the mammalian dentate gyrus good for?

A Treves, A Tashiro, MP Witter, EI Moser - Neuroscience, 2008 - Elsevier
In the mammalian hippocampus, the dentate gyrus (DG) is characterized by sparse and
powerful unidirectional projections to CA3 pyramidal cells, the so-called mossy fibers (MF) …

Sharpening the blades of the dentate gyrus: how adult‐born neurons differentially modulate diverse aspects of hippocampal learning and memory

G Berdugo‐Vega, S Dhingra, F Calegari - The EMBO Journal, 2023 - embopress.org
For decades, the mammalian hippocampus has been the focus of cellular, anatomical,
behavioral, and computational studies aimed at understanding the fundamental …

Contributions of adult neurogenesis to dentate gyrus network activity and computations

SN Tuncdemir, CO Lacefield, R Hen - Behavioural Brain Research, 2019 - Elsevier
Anatomical observations, theoretical work and lesion experiments have led to the idea that
an important function of the dentate gyrus of the mammalian hippocampus is pattern …

[HTML][HTML] Structure, function, and plasticity of hippocampal dentate gyrus microcircuits

P Jonas, J Lisman - Frontiers in neural circuits, 2014 - frontiersin.org
The hippocampus mediates several higher brain functions, such as learning, memory, and
spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role …

[HTML][HTML] On how the dentate gyrus contributes to memory discrimination

MT van Dijk, AA Fenton - Neuron, 2018 - cell.com
The dentate gyrus (DG) is crucial for behaviorally discriminating similar spatial memories,
predicting that DG place cells change (" remap") their relative spatial tuning (" place fields") …

Pattern separation in the dentate gyrus: a role for the CA3 backprojection

CE Myers, HE Scharfman - Hippocampus, 2011 - Wiley Online Library
Many theories of hippocampal function assume that area CA3 of hippocampus is capable of
performing rapid pattern storage, as well as pattern completion when a partial version of a …

Dentate gyrus contributes to retrieval as well as encoding: evidence from context fear conditioning, recall, and extinction

BE Bernier, AF Lacagnina, A Ayoub… - Journal of …, 2017 - Soc Neuroscience
Dentate gyrus (DG) is widely thought to provide a teaching signal that enables hippocampal
encoding of memories, but its role during retrieval is poorly understood. Some data and …