In mice, the contraction of the ciliary muscle via the administration of pilocarpine reduces the
zonular tension applied to the lens and activates the TRPV1-mediated arm of a dual …

Purpose: The lens uses circulating fluxes of ions and water that enter the lens at both poles
and exit at the equator to maintain its optical properties. We have mapped the subcellular …

Lens water transport generates a hydrostatic pressure gradient that is regulated by a dual-
feedback system that utilizes the mechanosensitive transient receptor potential vanilloid …

The ocular lens is an important determinant of overall vision quality whose refractive and
transparent properties change throughout life. The lens operates an internal microcirculation …

Purpose: Lenses have an intracellular hydrostatic pressure gradient to drive fluid from
central fiber cells to surface epithelial cells. Pressure is regulated by a feedback control …

Although the functionality of the lens water channels aquaporin 1 (AQP1; epithelium) and
AQP0 (fiber cells) is well established, less is known about the role of AQP5 in the lens. Since …

Abstract Aquaporin-5 (AQP5) regulates osmotic balance and transparency of the ocular lens
through facilitated diffusion of water and represents an integral component of the lens …

To function normally, all cells must maintain ion homeostasis, establish a membrane
potential, and regulate water content. These actions require active Na-K transport provided …

Purpose: The lens uses feedback to maintain zero pressure in its surface cells. Positive
pressures are detected by transient receptor potential vanilloid (TRPV4), which initiates a …

Until recently, the lens was thought to express only two aquaporin (AQP) water channels,
AQP1 and AQP0. In this study we confirm lenticular AQP5 protein expression by Western …