Abstract Currently, messenger RNA (mRNA)-based lipid nanoparticle formulations
revolutionize the clinical field. Cationic polymer-based complexes (polyplexes) represent an …

Messenger RNAs (mRNAs) present a great potential as therapeutics for the treatment and
prevention of a wide range of human pathologies, allowing for protein replacement …

Despite recent advances in the field of mRNA therapy, the lack of safe and efficacious
delivery vehicles with pharmaceutically developable properties remains a major limitation …

Abstract mRNA based gene therapies hold the potential to treat multiple diseases with
significant advantages over DNA based therapies, including rapid protein expression and …

There has been a progressive interest in the molecular design of polymers and lipids as
synthetic carriers for targeting therapeutic mRNA in vivo with the ability to circumvent …

Nanoparticles (NPs) formulated with cationic lipids and/or polymers have shown substantial
potential for systemic delivery of RNA therapeutics such as small interfering RNA (siRNA) for …

Messenger RNA (mRNA) is emerging as a promising therapeutic modality for a variety of
diseases. Because of the fragility and limited intracellular access of mRNA, the development …

Messenger RNA (mRNA) has recently come into focus as an emerging therapeutic class
with great potential for protein replacement therapy, cancer immunotherapy, regenerative …

Abstract Lipid-based colloidal particles have been extensively studied as systemic gene
delivery carriers. The topic that we would like to emphasize is the formulation/assembly of …

Though therapeutics based on messenger RNA (mRNA) have broad potential in
applications such as protein replacement therapy, cancer immunotherapy, and genomic …