The recent development of experimental methods for measuring chromatin state at single-
cell resolution has created a need for computational tools capable of analyzing these …

The recent development of experimental methods for measuring chromatin state at single-
cell resolution has created a need for computational tools capable of analyzing these …

Chromatin-state annotation using combinations of chromatin modification patterns has
emerged as a powerful approach for discovering regulatory regions and their cell type …

Deciphering mechanisms in cell-fate decisions requires single-cell holistic reconstructions of
multidimensional epigenomic states in transcriptional regulation. Here we develop CoTECH …

Single-cell measurement of chromatin states, including histone modifications and non-
histone protein binding, remains challenging. Here, we present a low-cost, efficient …

Technologies that profile chromatin modifications at single-cell resolution offer enormous
promise for functional genomic characterization, but the sparsity of the measurements and …

Chromatin profiling provides a versatile means to investigate functional genomic elements
and their regulation. However, current methods yield ensemble profiles that are insensitive …

Determining the genomic location of DNA‐binding proteins is essential to understanding
their function. Cleavage Under Targets and Release Using Nuclease (CUT&RUN) is a …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

Single-cell open chromatin profiling via scATAC-seq has become a mainstream
measurement of open chromatin in single-cells. Here we present epiAneufinder, an …