The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

S Lecca, FJ Meye, M Mameli - European Journal of …, 2014 - Wiley Online Library
The lateral habenula (LH b) is an epithalamic region with a crucial role in the regulation of
midbrain monoaminergic systems. Over the past few years a renewed interest in the LH b …

Circuits and functions of the lateral habenula in health and in disease

H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders

M Metzger, R Souza, LB Lima, D Bueno… - European Journal of …, 2021 - Wiley Online Library
The habenula (Hb) is a phylogenetically old epithalamic structure differentiated into two
nuclear complexes, the medial (MHb) and lateral habenula (LHb). After decades of search …

[HTML][HTML] Synaptic and cellular profile of neurons in the lateral habenula

FJ Meye, S Lecca, K Valentinova… - Frontiers in human …, 2013 - frontiersin.org
The lateral habenula (LHb) is emerging as a crucial structure capable of conveying
rewarding and aversive information. Recent evidence indicates that a rapid increase in the …

The lateral habenula and the serotonergic system

M Metzger, D Bueno, LB Lima - Pharmacology Biochemistry and Behavior, 2017 - Elsevier
The habenula (Hb) is an epithalamic structure differentiated into two nuclear complexes,
medial (MHb) and lateral habenula (LHb). After decades of relative neglect, interest in the …

[HTML][HTML] Understanding the habenula: A major node in circuits regulating emotion and motivation

JL Ables, K Park, I Ibañez–Tallon - Pharmacological Research, 2023 - Elsevier
Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

[HTML][HTML] Dysregulation of the lateral habenula in major depressive disorder

CA Browne, R Hammack, I Lucki - Frontiers in synaptic neuroscience, 2018 - frontiersin.org
Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in
the development of psychiatric disorders including major depressive disorder (MDD). This …

Habenula: crossroad between the basal ganglia and the limbic system

O Hikosaka, SR Sesack, L Lecourtier… - Journal of …, 2008 - Soc Neuroscience
There is a growing awareness that emotion, motivation, and reward values are important
determinants of our behavior. The habenula is uniquely positioned both anatomically and …

[HTML][HTML] Lateral habenula in the pathophysiology of depression

Y Yang, H Wang, J Hu, H Hu - Current opinion in neurobiology, 2018 - Elsevier
Depression is a devastating disorder with a combination of diverse symptoms such as low
self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort …

The habenula in psychiatric disorders: more than three decades of translational investigation

M Fakhoury - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
The habenula is an epithalamic structure located at the center of the dorsal diencephalic
conduction system, a pathway involved in linking forebrain to midbrain regions. Composed …