There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …

Cardiac arrhythmias are frequently seen in patients with dilated cardiomyopathy (DCM) and
can precipitate heart failure and death. In patients with non-ischaemic DCM, evidence for the …

Genetic interpretation of rare variants associated with arrhythmogenic cardiomyopathy
(ACM) is essential due to their diagnostic implications. New data may relabel previous …

Sudden cardiac death caused by malignant ventricular arrhythmias is the most important
cause of death in the industrialized world. Most of these lethal arrhythmias occur in the …

Inherited cardiac diseases comprise a wide and heterogeneous spectrum of diseases of the
heart, including the cardiomyopathies and the arrhythmic diseases in structurally normal …

Background: Genotype-phenotype correlations in dilated cardiomyopathy (DCM) and, in
particular, the effects of gene variants on clinical outcomes remain poorly understood …

The era of gene discovery and molecular medicine has had a significant impact on clinical
practice. Knowledge of specific genetic findings causative for or associated with human …

Over the past 2 decades, investigators in the field of cardiac genetics have evolved a
complex understanding of the pathophysiological basis of inherited cardiac diseases, which …

While the inherited cardiomyopathies and primary arrhythmogenic disorders are distinctly
different diseases, the genetic counseling issues can be very similar. 14 Collectively, these …

Cardiomyopathies are defined as diseases of the myocardium associated with cardiac
dysfunction ranging from lifelong symptomless forms to major health problems such as …