The immune functions of keratinocytes in skin wound healing

M Piipponen, D Li, NX Landén - International journal of molecular …, 2020 - mdpi.com
As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair
not only as structural cells but also exerting important immune functions. This review focuses …

The dynamics of the skin's immune system

AV Nguyen, AM Soulika - International journal of molecular sciences, 2019 - mdpi.com
The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Inflammatory microenvironment of skin wounds

Z Wang, F Qi, H Luo, G Xu, D Wang - Frontiers in immunology, 2022 - frontiersin.org
Wound healing is a dynamic and highly regulated process that can be separated into three
overlapping and interdependent phases: inflammation, proliferation, and remodelling. This …

Immune cells in cutaneous wound healing: a review of functional data from animal models

DM Chesko, TA Wilgus - International journal of molecular sciences, 2022 - mdpi.com
The healing of skin wounds involves the activation and recruitment of various immune cell
types, many of which are believed to contribute significantly to different aspects of the repair …

Cytokines and the skin barrier

KH Hänel, C Cornelissen, B Lüscher… - International journal of …, 2013 - mdpi.com
The skin is the largest organ of the human body and builds a barrier to protect us from the
harmful environment and also from unregulated loss of water. Keratinocytes form the skin …

Cellular and molecular mechanisms of skin wound healing

OA Peña, P Martin - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Epithelialization in wound healing: a comprehensive review

I Pastar, O Stojadinovic, NC Yin, H Ramirez… - Advances in wound …, 2014 - liebertpub.com
Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …

[HTML][HTML] Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

Y Jiang, LC Tsoi, AC Billi, NL Ward, PW Harms… - JCI insight, 2020 - ncbi.nlm.nih.gov
The skin serves as the primary interface between our body and the external environment
and acts as a barrier against entry of physical agents, chemicals, and microbes …

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

T Xiao, Z Yan, S Xiao, Y Xia - Stem cell research & therapy, 2020 - Springer
The skin, which serves as the first barrier of the human body, is particularly susceptible to
exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are …

Immune regulation of skin wound healing: mechanisms and novel therapeutic targets

J Larouche, S Sheoran, K Maruyama… - Advances in wound …, 2018 - liebertpub.com
Significance: The immune system plays a central role in orchestrating the tissue healing
process. Hence, controlling the immune system to promote tissue repair and regeneration is …