Stem-cell-mediated bone repair has been used in clinical trials for the regeneration of large
craniomaxillofacial defects, to slow the process of bone degeneration in patients with …

The deterioration of the human skeleton's capacity for self-renewal occurs naturally with age.
Osteoporosis affects millions worldwide, with current treatments including pharmaceutical …

Effective regeneration of bone defects often presents significant challenges, particularly in
patients with decreased tissue regeneration capacity due to extensive trauma, disease …

Bone is the most transplanted tissue human with 1 million procedures every year in Europe.
Surgical interventions for bone repair are required for varied reasons such as trauma …

Bone tissue engineering is a promising field of regenerative medicine in which cultured
cells, scaffolds, and osteogenic inductive signals are used to regenerate bone. This …

Bone marrow is a reservoir of pluripotent stem/progenitor cells for mesenchymal tissues.
Upon in vitro expansion, in vivo bone-forming efficiency of bone marrow stromal cells …

Bone has the capacity to regenerate and repair itself. However, this capacity may be
impaired or lost depending on the size of the defect or the presence of certain disease …

Skeletal stem cells confer to bone its innate capacity for regeneration and repair. Bone
regeneration strategies seek to harness and enhance this regenerative capacity for the …

Abstract Age-related (type-II) osteoporosis is a common and debilitating condition driven in
part by the loss of bone marrow (BM) mesenchymal stromal cells (MSC) and their osteoblast …

Bone marrow stromal stem cells (BMSCs) are adult multipotent cells, which have the
potential to differentiate into cell types of mesodermal origin, namely osteocytes, adipocytes …