Delivery of macromolecules to mammalian cells is a critical step for gene expression studies
and for gene therapy. Cationic liposomes are simple vehicles for delivering macromolecules …

Cationic liposomes have been studied as a potential carrier for delivering genes to cells for
the purpose of gene therapy. This report summarizes our efforts to characterize the in vivo …

Stable complexes of cationic liposomes with plasmid DNA were prepared by (1) including a
small amount of poly (ethylene glycol)-phospholipid conjugate or (2) condensing the DNA …

Cationic liposomes are considered to be safe vectors for gene transfer, but they are less
efficient at delivering DNA to cells when compared with retroviral vectors. Cationic …

Cationic liposomes spontaneously interact with the negatively charged DNA to form a stable
complex that promotes the gene transfer to cells. The mode of formation and the size of …

Cationic liposomes have been considered as a potential nonviral vector for gene delivery
because they possess low immunogenicity, unlike viral vectors. The gene transfer efficiency …

Cationic liposomes are well known to assist the delivery of genes and other nucleic acids to
cells in vitro. This has held out the tantalizing possibility that cationic liposome systems could …

Publisher Summary This chapter outlines the methodological aspects of gene delivery by a
novel set of lipidic transfection reagents, including cationic lipids, glycolipids, and pH …

Gene therapy, the concept which was initially proposed some 30 years ago and which may
come to fruition in the next decade, theoretically offers healing of human diseases at their …

Direct gene transfer for the treatment of human diseases requires a vector which can be
administered efficiently, safely and repeatedly. Cationic liposomes represent one of the few …