Breast cancer bone metastases (BCBM) result in serious skeletal morbidity. Although there
have been important advances in cancer treatment methods such as surgery and …

Background The development of bone metastasis from breast cancer results from a
functional interaction between tumor cells and osteoclasts or osteoblasts. The main aim of …

Breast cancer metastasis to the bone continues to be a major health problem, with
approximately 80% of advanced breast cancer patients expected to develop bone …

Breast cancer frequently metastasizes to bone, resulting in osteolytic lesions. These lesions,
formed by activated osteoclasts, cause pain, an increased susceptibility to fractures, and …

The presence of microcalcifications in the breast microenvironment, combined with the
growing evidences of the possible presence of osteoblast-like or osteoclast-like cells in the …

Background Bone metastasis is a main cause of morbidity in breast cancer. Since breast
cancer is a heterogeneous disease, the interactions of cancer cells with the skeletal host …

Background: This study aims to investigate:(a) the putative association between the
presence of microcalcifications and the expression of both epithelial-to-mesenchymal …

Bone metastases occur in 70% of patients with advanced breast cancer, causing severe
morbidity and increased mortality due to osteolytic lesions driven by osteoclasts (OCs) …

Bone is one of the most common sites of metastasis in patients with advanced breast cancer;
however, the mechanisms of bone metastasis remain to be fully elucidated. Animal models …

Introduction To minimize the severity of bone metastases and to delay their onset, it is
important to analyze the underlying biological mechanisms. The present study focused on …