A compressibility and compactibility study of real tableting mixtures: The impact of wet and dry granulation versus a direct tableting mixture

M Šantl, I Ilić, F Vrečer, S Baumgartner - International journal of …, 2011 - Elsevier
The purpose of this study was to investigate the influence of various powder agglomeration
processes on tableting mixture flow and compaction properties. Four different granulation …

[PDF][PDF] A compressibility and compactibility study of real tableting mixtures: the effect of granule particle size

M Šantl, I Ilić, F Vrečer, S Baumgartner - Acta pharmaceutica, 2012 - sciendo.com
This study investigates the effect of particle size on the compression characteristics of wet-
(fluid-bed granulation–FBG) and dry-granulated (slugging–DGS) tableting mixtures. Particle …

Systematic study of paracetamol powder mixtures and granules tabletability: Key role of rheological properties and dynamic image analysis

O Macho, Ľ Gabrišová, J Brokešová… - International Journal of …, 2021 - Elsevier
The aim of this systematic study was to analyze the granulometric and rheological behavior
of tableting mixtures in relation to tabletability by single tablet and lab-scale batch …

New insights into segregation during tabletting

S Lakio, S Siiriä, H Räikkönen, S Airaksinen… - International journal of …, 2010 - Elsevier
The aim of this study was to evaluate how different granule size distributions affect the tablet
compression process. The emphasis was on developing new analytic methods for …

The effect of particle fragmentation and deformation on the interparticulate bond formation process during powder compaction

M Eriksson, G Alderborn - Pharmaceutical research, 1995 - Springer
Purpose. The compression behaviour and the compactability of particles have been studied.
In addition, an expression describing the bond strength over a tablet cross section was …

[HTML][HTML] A classification system for tableting behaviors of binary powder mixtures

CC Sun - asian journal of pharmaceutical sciences, 2016 - Elsevier
The ability to predict tableting properties of a powder mixture from individual components is
of both fundamental and practical importance to the efficient formulation development of …

Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction

CK Tye, CC Sun, GE Amidon - Journal of pharmaceutical sciences, 2005 - Elsevier
It is well known that compression speed can have significant effects on the compaction
properties of pharmaceutical powders. This is a challenge during scale up and technology …

Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression

L Farber, KP Hapgood, JN Michaels, XY Fu… - International journal of …, 2008 - Elsevier
A model that describes the relationship between roller-compaction conditions and tablet
strength is proposed. The model assumes that compaction is cumulative during roller …

Particle size distribution and evolution in tablet structure during and after compaction

F Fichtner, Å Rasmuson, G Alderborn - International journal of …, 2005 - Elsevier
The objective of this study was to investigate the effect of the distribution in size of free-
flowing particles for the evolution in tablet structure and tablet strength. For sucrose and …

[HTML][HTML] Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures

T Osamura, Y Takeuchi, R Onodera, M Kitamura… - asian journal of …, 2018 - Elsevier
We previously determined “Tableting properties” by using a multi-functional single-punch
tablet press (GTP-1). We plotted “Compactability” on the x-axis against “Manufacturability” …