Acute-Phase Plasma Pigment Epithelium-Derived Factor Predicting Outcomes after Aneurysmal Subarachnoid Hemorrhage in the Elderly

M Nampei, Y Suzuki, H Nakajima, H Oinaka… - International Journal of …, 2024 - mdpi.com
Aneurysmal subarachnoid hemorrhage (SAH) has increased with the aging of the
population, but the outcome for elderly SAH patients is very poor. Therefore, predicting the …

[HTML][HTML] Increased plasma pigment epithelium-derived factor (PEDF) concentrations as a negative predictor of angiographic vasospasm after aneurysmal …

M Nampei, F Kawakita, R Asada, Y Suzuki… - Brain …, 2024 - Elsevier
Cerebral vasospasm remains a major determinant of delayed cerebral ischemia (DCI) and
poor outcomes after aneurysmal subarachnoid hemorrhage (SAH). This study was aimed to …

Alzheimer's disease: Elevated pigment epithelium-derived factor in the cerebrospinal fluid is mostly of systemic origin

V Lang, M Zille, C Infante-Duarte, S Jarius… - Journal of the …, 2017 - Elsevier
Pigment-epithelium derived factor (PEDF) is a neurotrophic factor with neuroprotective, anti-
tumorigenic, and anti-angiogenic effects. Elevated levels of PEDF have previously been …

Evaluation of alpha-II-spectrin breakdown products as potential biomarkers for early recognition and severity of aneurysmal subarachnoid hemorrhage

L Papa, K Rosenthal, F Silvestri, JC Axley, JM Kelly… - Scientific reports, 2018 - nature.com
This study assessed whether cytoskeletal protein alpha-II spectrin breakdown products
(SBDP150, SBDP145, and SBDP120) would identify the presence of aSAH and be …

Is pigment epithelium-derived factor level in cerebrospinal fluid a promising biomarker for early diagnosis of Alzheimer's disease?

S Yamagishi, Y Inagaki, M Takeuchi, N Sasaki - Medical hypotheses, 2004 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia in Western countries and
in Japan. Early diagnosis and treatment is needed to slow down the degenerative process …

Prognostic significance of white blood cell to platelet ratio in delayed cerebral ischemia and long-term clinical outcome after aneurysmal subarachnoid hemorrhage

W Zhang, Y Wang, Q Zhang, F Hou, L Wang… - Frontiers in …, 2023 - frontiersin.org
Objectives The ratio of white blood cell to platelet count (WPR) is considered a promising
biomarker in some diseases. However, its prediction of delayed cerebral ischemia (DCI) and …

D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study

J Liu, X Li, Z Chen, Q Cai, L Wang, Y Ye… - Neural Regeneration …, 2017 - journals.lww.com
Serum biomarkers may play a reliable role in predicting the outcomes of patients with
aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship …

The D-dimer/albumin ratio is a prognostic marker for aneurysmal subarachnoid Hemorrhage

W Wu, X Liu, Q Zhu, X Chen, B Sheng, J Zhang, W Li… - Brain sciences, 2022 - mdpi.com
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a severe neurological event
with limited treatment options, and little is known about its pathophysiology. There are few …

Effects of pigment epithelium-derived factor on traumatic brain injury

MY Terzi, P Casalis, V Lang, M Zille… - Restorative …, 2015 - content.iospress.com
Purpose: Pigment epithelium-derived factor (PEDF) is a multifunctional protein with
antiangiogenic, anti-inflammatory, neurotrophic and neurogenic properties. The effect of …

Pigment epithelium-derived factor plays a role in Alzheimer's disease by negatively regulating Aβ42

M Huang, W Qi, S Fang, P Jiang, C Yang, Y Mo… - …, 2018 - Springer
Alzheimer's disease (AD) is the most common cause of dementia. Pigment epithelium-
derived factor (PEDF), a unique neurotrophic protein, decreases with aging. Previous …