Emulating host-microbiome ecosystem of human gastrointestinal tract in vitro

GS Park, MH Park, W Shin, C Zhao, S Sheikh… - Stem cell reviews and …, 2017 - Springer
The human gut microbiome performs prodigious physiological functions such as production
of microbial metabolites, modulation of nutrient digestion and drug metabolism, control of …

Advances in modelling the human microbiome–gut–brain axis in vitro

CM Moysidou, RM Owens - Biochemical Society Transactions, 2021 - portlandpress.com
The human gut microbiome has emerged as a key player in the bidirectional communication
of the gut–brain axis, affecting various aspects of homeostasis and pathophysiology. Until …

Organoids, organs-on-chips and other systems, and microbiota

S May, S Evans, L Parry - Emerging Topics in Life Sciences, 2017 - portlandpress.com
The human gut microbiome is considered an organ in its entirety and has been the subject
of extensive research due to its role in physiology, metabolism, digestion, and immune …

Dissecting Gut‐Microbial Community Interactions using a Gut Microbiome‐on‐a‐Chip

J Lee, N Menon, CT Lim - Advanced Science, 2024 - Wiley Online Library
While the human gut microbiota has a significant impact on gut health and disease,
understanding of the roles of gut microbes, interactions, and collective impact of gut …

Gut-on-chip: Recreating human intestine in vitro

Y Xiang, H Wen, Y Yu, M Li, X Fu… - Journal of tissue …, 2020 - journals.sagepub.com
The human gut is important for food digestion and absorption, as well as a venue for a large
number of microorganisms that coexist with the host. Although numerous in vitro models …

Intestinal stem cell-on-chip to study human host-microbiota interaction

F Siwczak, E Loffet, M Kaminska, H Koceva… - Frontiers in …, 2021 - frontiersin.org
The gut is a tubular organ responsible for nutrient absorption and harbors our intestinal
microbiome. This organ is composed of a multitude of specialized cell types arranged in …

Ex vivo systems to study host–microbiota interactions in the gastrointestinal tract

G Roeselers, M Ponomarenko, S Lukovac… - Best Practice & …, 2013 - Elsevier
It is increasingly apparent that the microbial ecosystems in the mammalian gastrointestinal
tract play an intricate role in health and disease. There is a growing interest in the …

Gut-on-chip for ecological and causal human gut microbiome research

S Moossavi, MC Arrieta, A Sanati-Nezhad… - Trends in …, 2022 - cell.com
There is a growing interest to understand if and how the gut microbiome is causally linked to
the pathogenesis and/or progression of diseases. While in vitro cell line models are …

[HTML][HTML] Organoids and organs-on-chips: Insights into human gut-microbe interactions

J Puschhof, C Pleguezuelos-Manzano, H Clevers - Cell host & microbe, 2021 - cell.com
The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …

Contributions of the microbiome to intestinal inflammation in a gut-on-a-chip

MS Jeon, YY Choi, SJ Mo, JH Ha, YS Lee, HU Lee… - Nano …, 2022 - Springer
The intestinal microbiome affects a number of biological functions of the organism. Although
the animal model is a powerful tool to study the relationship between the host and microbe …