Adult T-cell leukemia/lymphoma (ATL) is triggered by infection with human T-cell
lymphotropic virus-1 (HTLV-1). Here, we describe the reprogramming of pyrimidine …

The DNA methylation inhibitor azacitidine (5-azacytidine) is used against myelodysplastic
syndrome and acute myeloid leukemia, but drug resistance is an ongoing, intractable …

Uridine-cytidine kinase like-1 (UCKL-1) is a largely uncharacterized protein with high
sequence similarity to other uridine-cytidine kinases (UCKs). UCKs play an important role in …

Enhanced nucleoside metabolism is one of the hallmarks of cancer. Uridine-cytidine kinase
2 (UCK2) is a rate-limiting enzyme of the pyrimidine salvage synthesis pathway to …

Uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine and cytidine as well
as the pharmacological activation of several cytotoxic pyrimidine ribonucleoside analogues …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy
derived from early T cell progenitors. Since relapsed T-ALL is associated with a poor …

The mechanism of HTLV-1 transformation of cells to Adult T cell leukemia (ATL) remains not
fully understood. Currently, the viral Tax oncoprotein is known to be required to initiate …

Uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine, cytidine, and several
pyrimidine ribonucleoside analogs. We overexpressed and purified the two known isoforms …

Adult T-cell leukemia (ATL) is a malignancy of mature CD4+ T cells that is etiologically
associated with the infection of human T-cell leukemia virus type 1 (HTLV-1), an exogenous …

Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and
differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it …