Background: Substance use disorder emerges in a small proportion of drug users and has
the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate …

Only a subgroup of human drug users progress from initial drug taking to drug addiction. The
learned associations between the effects of the drug and the environment in which it is …

Rationale and objectives Drug-seeking behavior occurs more readily in some individuals
than others. This phenomenon is considered in studies of drug self-administration in which …

The development and maintenance of cocaine addiction depend heavily on learned reward-
environment associations that can induce drug-seeking behavior and relapse …

Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

The expression phase of cocaine-induced conditioned place preference (CPP) represents a
cocaine-seeking behavior triggered by contextual cues associated with the rewarding effects …

Rationale: In previous comparisons with C57BL/6J mice, DBA/2J mice have been
characterized as” hyporesponsive” to cocaine's rewarding effect in the conditioned place …

Outbred, male Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively) based on cocaine-induced locomotor activity in an …

Sex differences in cocaine's mechanisms of action and behavioral effects have been widely
reported. However, little is known about how sex influences intracellular signaling cascades …

Men and women respond differently to the subjective effects of cocaine and cocaine-
associated cues, which has implications for the development and maintenance of cocaine …