Diabetic cardiomyopathy is a result of diabetes-induced changes in the structure and
function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but …

Diabetic cardiomyopathy and heart failure have been recognized as the leading causes of
mortality among diabetics. Diabetic cardiomyopathy has been characterized primarily by the …

Significance: Cardiac function is energetically demanding, reliant on efficient well-coupled
mitochondria to generate adenosine triphosphate and fulfill the cardiac demand. Predictably …

Cardiovascular disease is common in patients with diabetes and is a significant contributor
to the high mortality rates associated with diabetes. Heart failure is common in diabetic …

Significance: Diabetes is an important risk factor for the development of heart failure (HF).
Given the increasing prevalence of diabetes in the population, strategies are needed to …

Type 2 diabetes is a redox disease. Oxidative stress and chronic inflammation induce a
switch of metabolic homeostatic set points, leading to glucose intolerance. Several diabetes …

Given their essential function in aerobic metabolism, mitochondria are intuitively of interest
in regard to the pathophysiology of diabetes. Qualitative, quantitative, and functional …

Many diabetic patients suffer from a cardiomyopathy that cannot be explained by poor
coronary perfusion. Reactive oxygen species (ROS) have been proposed to contribute to …

Despite being first described 45 years ago, the existence of a distinct diabetic
cardiomyopathy remains controversial. Nonetheless, it is widely accepted that the diabetic …

Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in
various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is …