Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …

Enhancers are distally located genomic cis-regulatory elements that integrate
spatiotemporal cues to coordinate gene expression in a tissue-specific manner during …

The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Temporal and spatial specificity of gene expression is highly regulated through a rich milieu
of regulatory DNAs embedded in the genome. Enhancers represent a major class of …

Developmental enhancers mediate on/off patterns of gene expression in specific cell types
at particular stages during metazoan embryogenesis. They typically integrate multiple …

Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …

During embryogenesis, precise gene transcription in space and time requires that distal
enhancers and promoters communicate by physical proximity within gene regulatory …

It is now well accepted that cell-type specific gene regulation is under the purview of
enhancers. Great strides have been made recently to characterize and identify enhancers …