HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its
mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA …

The mechanism by which HLA-DM (DM) promotes exchange of peptides bound to HLA-DR
(DR) is still unclear. We have shown that peptide interaction with DR1 can be considered a …

Peptide binding induces conformational changes in class II MHC proteins that have been
characterized using a variety of hydrodynamic and spectroscopic approaches, but these …

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …

Background: Class II major histocompatibility complex (MHC) proteins are cell surface
glycoproteins that bind peptides and present them to T cells as part of the mechanism for …

The class II MHC homolog HLA-DM catalyzes exchange of peptides bound to class II MHC
proteins, and is an important component of the Ag presentation machinery. The mechanism …

The mechanism by which the peptide exchange factor HLA-DM catalyzes peptide loading
onto structurally homologous class II MHC proteins is an outstanding problem in antigen …

Determination of the crystal structure of class II: peptide complexes has shown that in
addition to pocket interactions involving the side chains of the peptide, peptide binding to …

Peptides bind MHC class II molecules through a thermodynamically nonadditive process
consequent to the flexibility of the reactants. Currently, how the specific outcome of this …

HLA-DM catalyzes peptide dissociation and exchange in class II MHC molecules through a
mechanism that has been proposed to involve the disruption of specific components of the …