Optic neuropathies refer to a group of ocular disorders with abnormalities or dysfunction of
the optic nerve, sharing a common pathophysiology of retinal ganglion cell (RGC) death and …

Following optic nerve injury associated with acute or progressive diseases, retinal ganglion
cells (RGCs) of adult mammals degenerate and undergo apoptosis. These diseases have …

The retinal ganglion cells (RGCs) are not able to regenerate following optic nerve injury
resulting in an irreversible vision loss in patients with optic neuropathies including …

The prospects of stem cell therapy for retinal ganglion cell (RGC) degeneration in human:
RGC degeneration is a common pathologic cause of glaucoma and optic neuropathies …

Objective Any damage to the optic nerve can potentially lead to degeneration of non-
regenerating axons and ultimately death of retinal ganglion cells (RGCs) that in most cases …

Retinal and optic nerve diseases are degenerative ocular pathologies which lead to
irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer …

Conclusions: Although we have performed an in depth comparison of three common human-
derived MSC types and identified DPSCs as the most efficacious cell type for RGC …

Background Optic-nerve injury results in impaired transmission of visual signals to central
targets and leads to the death of retinal ganglion cells (RGCs) and irreversible vision loss …

Loss of sight due to irreversible retinal neurodegeneration imposes a significant disease
burden on both patients and society. Glaucoma and age-related macular degeneration are …

Background: Restoration of vision in patients blinded by advanced optic neuropathies
requires technologies that can either 1) salvage damaged and prevent further degeneration …