Rationale: There is increasing evidence that emphysema is associated with primary loss of
pulmonary capillary endothelium. Plasma levels of endothelial microparticles (EMPs), small …

Rationale: Basic research implicates alveolar endothelial cell apoptosis in the pathogenesis
of chronic obstructive pulmonary disease (COPD) and emphysema. However, information …

Accumulating evidence suggests that cell injury in lung tissues is closely connected to
disease progression in chronic obstructive pulmonary disease (COPD). Microparticles (MPs) …

Rationale: Circulating microparticles (MPs) are submicron membrane fragments shed from
damaged or activated vascular cells. Endothelial MPs are a biological marker of …

Cell-derived microparticles are small (0.1–1 μm) vesicles shed by most eukaryotic cells
upon activation or during apoptosis. Microparticles carry on their surface, and enclose within …

Rationale The influence of COPD exacerbation on the endothelium is not completely
understood. Circulating endothelial microparticles (EMPs) are membrane vesicles in …

Circulating endothelial microparticles (EMPs) are emerging as biomarkers of chronic
obstructive pulmonary disease (COPD) in individuals exposed to cigarette smoke (CS), but …

Rationale: Procoagulant microparticles constitute valuable hallmarks of cell damage.
Microparticles also behave as cellular effectors. Objectives: We hypothesized that the extent …

BACKGROUND: Endothelial and leukocytes-derived microparticles (EMPs and LMPs,
respectively) are increased in patients with pulmonary hypertension (PH). We hypothesized …

Emphysema due to cigarette smoking is characterized by a loss of alveolar structures. We
hypothesize that the disappearance of alveoli involves apoptosis of septal endothelial cells …