To manipulate the intracellular milieu of rabbit platelets, permeabilization was performed
using digitonin. Permeabilized platelets showed dose-dependent release of histamine …

In previous reports, we have provided evidence indicating that newly formed histamine is an
intracellular messenger in human platelets. The involvement of protein kinase C (PKC) and …

抄録 Digitonin-permeabilized rabbit platelets released serotonin dose-dependently in
response to cupric phenanthroline, which is a mild oxidant which catalyzes the formation of …

The localization of histamine formed by human platelets in response to agonists was
evaluated. 87±5% of the histamine in a suspension of platelets exposed to phorbol-12 …

After human platelets have been rendered permeable to small molecules by high voltage
electric discharges, addition of buffered micromolar concentrations of Ca2+ causes an ATP …

The influence of histamine on human platelet function was studied by measuring the uptake
of [3 H]-histamine and by evaluating the effect of histamine on Ca 2+ influx and on …

1 Addition of thrombin enhances secretion of both [14C] serotonin and β‐N‐
acetylglucosaminidase induced by Ca2+ in human platelets rendered permeable by …

Micromolar levels of free calcium ions added to the extracellular medium elicit secretion of
serotonin from electropermeabilized bovine platelets in the presence of millimolar levels of …

Histamine, a major constituent of the amine-storage organelles in pig platelets, is taken up
by intact platelets in only trace amounts under conditions where 70% of 14 C-serotonin is …

In the presence of EDTA, serotonin release from platelets induced by the calcium-ionophore
A23187 is accompanied by alterations of the ultrastructure and changes in light transmission …