Sensitization of motor activity is a behavioural test to evaluate the effects of
psychostimulants. Conditioned place preference (CPP) is an associative learning procedure …

The rewarding properties of drugs in zebrafish can be studied using the conditioned place
preference (CPP) paradigm. Most devices that have been used for CPP consist of two-half …

Prior exposure to drugs of abuse may facilitate addiction. It has been described that pre-
exposure to nicotine can increase or, contrarily, prevent conditioned place preference …

Conditioned place preference (CPP) paradigm in zebrafish has been used to measure drug
reward, but there is limited research on CPP reinstatement to determine relapse …

Studies with mice and rats have demonstrated that nicotine induces a Pavlovian
conditioning denominated conditioned place preference (CPP). This behavioral paradigm is …

Addiction is a complex psychiatric disorder characterised by a spectrum of compulsive drug-
seeking behaviours and a persistent tendency to relapse (return to drug taking) even after …

Background Nicotine withdrawal syndrome is a major clinical problem. Animal models with
sufficient predictive validity to support translation of pre-clinical findings to clinical research …

Studies using mice and rats have demonstrated that nicotine induces a conditioned place
preference (CPP), with more effective results obtained by using biased procedures …

Background Zebrafish are growing in use as a model for understanding drug dependence
and addiction. Sensitization paradigms have been a useful tool in identifying mechanisms …

Addiction and substance abuse are found ubiquitously throughout human society. In the
United States, these disorders are responsible for amassing hundreds of billions of dollars in …