Background: c-mesenchymal epithelial transition factor receptor (c-MET) and fibroblast
growth factor receptor 2 (FGFR2) amplification have been identified as factors associated …

Background: Fibroblast growth factors (FGF) and their receptors are complex intracellular
pathway that controls cellular proliferation and tumour growth and invasion. FGFR …

Fibroblast growth factor receptor-2 (FGFR2) gene is amplified in up to 15% of patients with
gastric cancer (GC). However, the prognostic significance of FGFR2 amplification has been …

Background Recurrent FGFR2 amplification is observed in gastroesophageal cancers but
clinical implications are unknown. We investigated the association of FGFR2 amplification …

Background: Fibroblast growth factors and their receptors regulate key cellular functions,
such as proliferation, differentiation and survival. Herein, we studied the prevalence and …

Background: In preclinical gastric cancer (GC) models, FGFR2 amplification was associated
with increased tumour cell proliferation and survival, and drugs targeting this pathway are …

Background: The fibroblast growth factor receptor (FGFR) tyrosine kinase family, which is
comprised of four kinases that differentially respond to 18 FGF ligands, has long been …

Objective Fibroblast growth factor receptor 2 (FGFR2) has been proposed as a novel
druggable target in unresectable gastric cancer. FGFR2 alteration has been reported as …

Purpose: FGFR2 amplification is associated with poor prognosis in advanced gastric cancer
and its subclonal heterogeneity has been revealed. Here, we examined whether circulating …

FGFR2 gene amplification, and resulting FGFR2 protein overexpression, is rare in gastric
cancer patients, and development of an accurate and widely available method for mass …