Extracellular matrix dynamics: tracking in biological systems and their implications

M Hu, Z Ling, X Ren - Journal of Biological Engineering, 2022 - Springer
The extracellular matrix (ECM) constitutes the main acellular microenvironment of cells in
almost all tissues and organs. The ECM not only provides mechanical support, but also …

Extracellular matrix in lung development, homeostasis and disease

Y Zhou, JC Horowitz, A Naba, N Ambalavanan… - Matrix Biology, 2018 - Elsevier
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …

Extracellular matrix dynamics in development and regenerative medicine

WP Daley, SB Peters, M Larsen - Journal of cell science, 2008 - journals.biologists.com
The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation,
survival, shape, migration and differentiation. Far from being a static structure, the ECM is …

[HTML][HTML] Chronic lung diseases: entangled in extracellular matrix

JK Burgess, MC Harmsen - European Respiratory Review, 2022 - Eur Respiratory Soc
The extracellular matrix (ECM) is the scaffold that provides structure and support to all
organs, including the lung; however, it is also much more than this. The ECM provides …

[HTML][HTML] Engineering ECM signals into biomaterials

RJ Wade, JA Burdick - Materials Today, 2012 - Elsevier
Historically, tissue engineering focused primarily on the delivery of soluble factors within
relatively static scaffolds; yet, increasing evidence indicates that the native, dynamic three …

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

TR Cox, JT Erler - Disease models & mechanisms, 2011 - journals.biologists.com
Dynamic remodeling of the extracellular matrix (ECM) is essential for development, wound
healing and normal organ homeostasis. Life-threatening pathological conditions arise when …

The extracellular matrix–the under‐recognized element in lung disease?

JK Burgess, T Mauad, G Tjin, JC Karlsson… - The Journal of …, 2016 - Wiley Online Library
The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM)
contains the main building blocks of both components. The ECM provides physical support …

Matrix, mesenchyme, and mechanotransduction

DJ Tschumperlin - Annals of the American Thoracic Society, 2015 - atsjournals.org
The extracellular matrix (ECM) of the lung serves as both a scaffold for resident cells and a
mechanical support for respiratory function. The ECM is deposited during development and …

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

G Burgstaller, B Oehrle, M Gerckens… - European …, 2017 - Eur Respiratory Soc
The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and
provides mechanical stability and elastic recoil, which are essential for physiological lung …

Exploring the extracellular matrix in health and disease using proteomics

IN Taha, A Naba - Essays in biochemistry, 2019 - portlandpress.com
The extracellular matrix (ECM) is a complex assembly of hundreds of proteins that
constitutes the scaffold of multicellular organisms. In addition to providing architectural and …