ABSTRACT Introduction: Influenza Virus-like Particles (VLPs) are one of the most promising
vaccine strategies to complement traditional egg-based processes and contribute to …

Influenza virus-like particle vaccines are one of the most promising ways to respond to the
threat of future influenza pandemics. VLPs are composed of viral antigens but lack nucleic …

Background Each year, influenza is responsible for hundreds of thousand cases of illness
and deaths worldwide. Due to the virus' fast mutation rate, the World Health Organization …

Influenza remains one of the major public health concerns because it causes annual
epidemics and can potentially instigate a global pandemic. Numerous countermeasures …

The establishment of cell culture‐derived vaccine production requires the development of
appropriate downstream processes. Until today, many of the downstream methods applied …

During the last decade, the spectre of an influenza pandemic of avian origin has led to a
revision of national and global pandemic preparedness plans and has stressed the need for …

There is an urgent need to develop novel approaches for vaccination against emerging
pathogenic avian influenza viruses as a priority for pandemic preparedness. Influenza virus …

The influenza virus continuously undergoes antigenic evolution requiring manufacturing,
validation and release of new seasonal vaccine lots to match new circulating strains …

The influenza pandemic of 2009 demonstrated the inability of the established global
capacity for egg-based vaccine production technology to provide sufficient vaccine for the …

Influenza virus dominant antigens presentation using virus like particle (VLP) approach is
attractive for the development of new generation of influenza vaccines. Mammalian cell …