For many years, the definition of appropriate anti-infective therapy has relied on the concept
of timely commencement of drug treatment with the spectrum appropriate for the pathogen …

Purpose: TDM is measurement of drug concentration in biological fluid to optimize patient's
drug therapy. Therapeutic drug monitoring of antibiotics is very crucial as nowadays …

For the optimization of dosing regimens of anti-infective agents, it is imperative to have a
good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever …

Due to variability in pharmacokinetics and pharmacodynamics, clinical outcomes of
antimicrobial drug therapy vary between patients. As such, personalised medication …

Background: Therapeutic drug monitoring (TDM) of anti-infective drugs is an increasingly
complex field, given that in addition to the patient and drug as 2 usual determinants, its …

Optimizing the prescription of antimicrobials is required to improve clinical outcome from
infections and to reduce the development of antimicrobial resistance. One such method to …

Since the Journal of Antimicrobial Chemotherapy was first published in 1975, papers
addressing therapeutic drug monitoring (TDM) have been a regular feature. Initially they …

Therapeutic drug monitoring (TDM) of antibiotics has been practiced for more than half a
century, but it is still not widely applied for infected patients. It has a traditional focus on …

Optimal use of antimicrobial agents is dependent on a multitude of factors. Empiric therapy
should be based on the patient's underlying disease states, the most likely organisms …

Therapeutic drug monitoring (TDM) of plasma samples is used in many circumstances to
adjust pharmaceutics to desired concentrations. It is predominantly employed for drugs with …