In 2005, the Lancet Neonatal Survival Series1 highlighted the fact that 4 million babies die in
the neonatal period; 99% of these deaths arise in low-income and middle-income countries …

Background Although therapeutic hypothermia reduces death or disability after neonatal
encephalopathy in high-income countries, its safety and efficacy in low-income and middle …

Neonatal encephalopathy (NE) secondary to intrapartum asphyxia remains a major cause of
post-natal death and permanent neurological deficits worldwide. Supportive therapy has …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

Background: This is a phase 4 study of infants registered with the UK TOBY Cooling
Register from December 2006 to February 2008. The registry was established on …

Although selective or whole body cooling combined with optimal intensive care improves
outcomes following neonatal encephalopathy in high-income countries, the safety and …

Three ongoing challenges have arisen after the introduction of therapeutic hypothermia (TH)
as standard of care for term newborns with moderate or severe perinatal asphyxia:(i) to …

Recent evidence suggests that the current ILCOR guidelines regarding hypothermia for the
treatment of neonatal encephalopathy need urgent revision. In 2005 when the current …

Background A hypoxic-ischaemic insult occurring around the time of birth may result in an
encephalopathic state characterised by the need for resuscitation at birth, neurological …

Background Whether hypothermic therapy improves neurodevelopmental outcomes in
newborn infants with asphyxial encephalopathy is uncertain. Methods We performed a …