Single-stranded genomic DNA can fold into G-quadruplex (G4) structures or form DNA: RNA
hybrids (R loops). Recent evidence suggests that such non-canonical DNA structures affect …

The establishment of cell identity during embryonic development involves the activation of
specific gene expression programmes and is underpinned by epigenetic factors including …

Background Four-stranded G-quadruplexes (G4s) are DNA secondary structures in the
human genome that are primarily found in active promoters associated with elevated …

Four‐stranded G‐rich DNA structures called G‐quadruplexes have been the subject of
increasing interest recently. Experimental and computational techniques have been used to …

The G-quadruplex is an alternative DNA structural motif that is considered to be functionally
important in the mammalian genome for transcriptional regulation, DNA replication and …

Abstract G-quadruplexes (G4s) are nucleic acid secondary structures that form within
guanine-rich DNA or RNA sequences. G4 formation can affect chromatin architecture and …

Abstract G-quadruplex (G4) is a noncanonical secondary structure of DNA or RNA which
can enhance or repress gene expression, yet the underlying molecular mechanism remains …

G-rich DNA sequences can form four-stranded G-quadruplex (G4) secondary structures and
are linked to fundamental biological processes such as transcription, replication and …

Abstract G-quadruplexes (G4s) are four-stranded DNA secondary structures that form in
guanine-rich regions of the genome. G4s have important roles in transcription and …

To understand how potential for G-quadruplex formation might influence regulation of gene
expression, we examined the 2 kb spanning the transcription start sites (TSS) of the 18 217 …