Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer
and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be …

Higher eukaryotic development is a complex and tightly regulated process, whereby
transcription factors (TFs) play a key role in controlling the gene regulatory networks …

Cancer is a multi-step process and requires constitutive expression/activation of
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …

Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Abstract Cancer Stem Cells (CSCs) are now considered the primary" seeds" for the onset,
development, metastasis, and recurrence of tumors. Despite therapeutic breakthroughs …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Transcriptional regulation is often the convergence point of oncogenic signaling. It is not
surprising, therefore, that aberrant gene expression is a hallmark of cancer. Transformed …