Modelling COPD in mice

R Vlahos, S Bozinovski, RC Gualano, M Ernst… - Pulmonary …, 2006 - Elsevier
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airflow
limitation, neutrophilic inflammation, macrophage accumulation, and the production of …

Animal models of chronic obstructive pulmonary disease

M Fricker, A Deane, PM Hansbro - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of
mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for …

Preclinical murine models of chronic obstructive pulmonary disease

R Vlahos, S Bozinovski - European journal of pharmacology, 2015 - Elsevier
Abstract Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health
burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated …

Recent advances in pre-clinical mouse models of COPD

R Vlahos, S Bozinovski - Clinical science, 2014 - portlandpress.com
COPD (chronic obstructive pulmonary disease) is a major incurable global health burden
and will become the third largest cause of death in the world by 2020. It is currently believed …

What can in vitro models of COPD tell us?

DI Krimmer, BGG Oliver - Pulmonary pharmacology & therapeutics, 2011 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterised
by chronic bronchitis, largely irreversible remodelling of the small airways, and …

[HTML][HTML] Understanding the relevance of the mouse cigarette smoke model of COPD: peering through the smoke

RW Vandivier, M Ghosh - American Journal of Respiratory Cell and …, 2017 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is one of the most important threats to public
health because of its prevalence, economic cost, and impact on death and disability …

Models for COPD involving cigarette smoke

PA Martorana, E Cavarra, M Lucattelli… - Drug Discovery Today …, 2006 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and
mortality throughout the world. Its impact has resulted in dynamic research into the …

Cigarette smoke exposure as a model of inflammation associated with COPD

S Eltom, C Stevenson, MA Birrell - Current protocols in …, 2013 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation resulting from inflammation‐driven pathologies in the lungs that are a …

The composition of cigarette smoke determines inflammatory cell recruitment to the lung in COPD mouse models

G John, K Kohse, J Orasche, A Reda… - Clinical …, 2014 - portlandpress.com
COPD (chronic obstructive pulmonary disease) is caused by exposure to toxic gases and
particles, most often CS (cigarette smoke), leading to emphysema, chronic bronchitis, mucus …

Animal models of cigarette smoke-induced COPD

JL Wright, A Churg - Chest, 2002 - Elsevier
Objectives To review the animal models of COPD, and to compare these data to those found
in humans. Results Smoke-induced animal models can produce emphysema, although the …