Regression of murine lung tumors by the let-7 microRNA
P Trang, PP Medina, JF Wiggins, L Ruffino, K Kelnar… - Oncogene, 2010 - nature.com
MicroRNAs (miRNAs) have recently emerged as an important new class of cellular
regulators that control various cellular processes and are implicated in human diseases …
regulators that control various cellular processes and are implicated in human diseases …
The let-7 microRNA reduces tumor growth in mouse models of lung cancer
A Esquela-Kerscher, P Trang, JF Wiggins, L Patrawala… - Cell cycle, 2008 - Taylor & Francis
MicroRNAs have been increasingly implicated in human cancer and interest has grown
about the potential to use microRNAs to combat cancer. Lung cancer is the most prevalent …
about the potential to use microRNAs to combat cancer. Lung cancer is the most prevalent …
The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells
CD Johnson, A Esquela-Kerscher, G Stefani, M Byrom… - Cancer research, 2007 - AACR
MicroRNAs play important roles in animal development, cell differentiation, and metabolism
and have been implicated in human cancer. The let-7 microRNA controls the timing of cell …
and have been implicated in human cancer. The let-7 microRNA controls the timing of cell …
Suppression of non-small cell lung tumor development by the let-7 microRNA family
MS Kumar, SJ Erkeland, RE Pester… - Proceedings of the …, 2008 - National Acad Sciences
Many microRNAs (miRNAs) target mRNAs involved in processes aberrant in tumorigenesis,
such as proliferation, survival, and differentiation. In particular, the let-7 miRNA family has …
such as proliferation, survival, and differentiation. In particular, the let-7 miRNA family has …
The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice
X He, J Chen, Z Zhang, C Li, Q Peng… - Journal of cancer research …, 2010 - Springer
Purpose Down-regulation of let-7 microRNA (miRNA) plays an important role in the
pathogenesis of lung cancer. k-Ras and c-Myc, two key oncogenes in lung cancer, have …
pathogenesis of lung cancer. k-Ras and c-Myc, two key oncogenes in lung cancer, have …
let-7 microRNAs in development, stem cells and cancer
I Büssing, FJ Slack, H Großhans - Trends in molecular medicine, 2008 - cell.com
MicroRNAs (miRNAs) are small noncoding RNAs,∼ 22 nucleotides in length, that repress
target messenger RNAs (mRNAs) through an antisense mechanism. The let-7 miRNA was …
target messenger RNAs (mRNAs) through an antisense mechanism. The let-7 miRNA was …
MicroRNAs as a potential magic bullet in cancer
FJ Slack, JB Weidhaas - 2006 - Future Medicine
Genes that control cell differentiation and development are frequently mutated in human
cancer. Micro (mi) RNAs are small regulatory RNAs that are emerging as important …
cancer. Micro (mi) RNAs are small regulatory RNAs that are emerging as important …
let‐7 and miR‐17‐92: Small‐sized major players in lung cancer development
H Osada, T Takahashi - Cancer science, 2011 - Wiley Online Library
MicroRNA (miRNA)‐encoding small non‐coding RNA have been recognized as important
regulators of a number of biological processes that inhibit the expression of hundreds of …
regulators of a number of biological processes that inhibit the expression of hundreds of …
The role of let-7 in cell differentiation and cancer
B Boyerinas, SM Park, A Hau… - Endocrine-related …, 2010 - erc.bioscientifica.com
MicroRNAs (miRNAs or miRs) are small noncoding RNAs capable of regulating gene
expression at the translational level. Current evidence suggests that a significant portion of …
expression at the translational level. Current evidence suggests that a significant portion of …
Function and regulation of let-7 family microRNAs
JL Su, PS Chen, G Johansson, ML Kuo - Microrna, 2012 - ingentaconnect.com
MicroRNAs (miRNAs) are a group of small noncoding RNAs capable of regulating specific
gene expression. Let-7 miRNA was first discovered in Caenorhabditis elegans and it is …
gene expression. Let-7 miRNA was first discovered in Caenorhabditis elegans and it is …