Importance Altered neurodevelopmental trajectories are thought to reflect heterogeneity in
the pathophysiologic characteristics of schizophrenia, but whether neural indicators of these …

In a recent machine learning study classifying “brain age” based on cross-sectional
neuroanatomical data, clinical high-risk (CHR) individuals were observed to show deviation …

First episode psychosis (FEP), and subsequent diagnosis of schizophrenia or
schizoaffective disorder, predominantly occurs during late adolescence, is accompanied by …

Importance Psychosis-risk studies have examined help-seeking adolescents and young
adults. Population-based studies evaluating psychotic symptoms and neurocognitive …

Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …

Structural brain abnormalities are central to schizophrenia (SZ), but it remains unknown
whether they are linked to dysmaturational processes crossing diagnostic boundaries …

Many of the major neuropsychiatric illnesses, including schizophrenia, have a typical age of
onset in late adolescence. Late adolescence may reflect a critical period in brain …

BackgroundClinical implementation of risk calculator models in the clinical high-risk for
psychosis (CHR-P) population has been hindered by heterogeneous risk distributions …

To date, the MRI-based individualized prediction of psychosis has only been demonstrated
in single-site studies. It remains unclear if MRI biomarkers generalize across different …

BACKGROUND: The at-risk mental state for psychosis (ARMS) has been associated with
abnormal structural brain dynamics underlying disease transition or non-transition. To date …