Hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis and increased levels of
glucocorticoid hormones in patients with depression have mostly been ascribed to impaired …

% Hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis has been reliably
observed in patients with major depression. One of the primary features of this HPA axis …

Clinical studies have demonstrated hyperactivity of the hypothalamic–pituitary–adrenal
(HPA) axis and increased levels of cortisol in patients with major depression, because of an …

Increased levels of glucocorticoid hormones—the main product of the hypothalamic‐pituitary‐
adrenal (HPA) axis—have been considered to be “depressogenic,” but this notion has …

Objective: Changes in the hypothalamic-pituitary-adrenocortical (HPA) system are
characteristic of depression. Because the effects of glucocorticoids are mediated by …

Clinical studies have demonstrated an impairment of glucocorticoid receptor (GR)-mediated
negative feedback on the hypothalamic–pituitary–adrenal (HPA) axis in patients with major …

Clinical studies have demonstrated an impairment of glucocorticoid receptor (GR)-mediated
negative feedback on the hypothalamus–pituitary–adrenal (HPA) axis in patients with major …

Major alterations of the hypothalamic–pituitary–adrenocortical (HPA) system that can be
reversed by successful antidepressant therapy are often seen in depressed patients …

Through expression of a glucocorticoid receptor (GR) antisense RNA in brain, we have
produced transgenic mice with an hyperactive hypothalamic-pituitary-adrenocortical (HPA) …

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that in its
unactivated form resides primarily in the cytoplasm. After being bound by steroid, the GR …