Interleukin-6 signaling in triple negative breast cancer cells elicits the annexin A1/formyl peptide receptor 1 axis and affects the tumor microenvironment

L Vecchi, STS Mota, MAP Zóia, IC Martins… - Cells, 2022 - mdpi.com
Annexin A1 (AnxA1) is a pleiotropic protein that exerts essential roles in breast cancer (BC)
growth and aggressiveness. In our previous work, we described the autocrine signaling of …

[HTML][HTML] Inhibition of the AnxA1/FPR1 autocrine axis reduces MDA-MB-231 breast cancer cell growth and aggressiveness in vitro and in vivo

L Vecchi, MAP Zóia, TG Santos… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Breast Cancer (BC) is a highly heterogeneous disease whose most aggressive behavior is
displayed by triple-negative breast cancer (TNBC), which lacks an efficient targeted therapy …

Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer

R Du, B Liu, L Zhou, D Wang, X He, X Xu… - Cell Death & …, 2018 - nature.com
Abstract Annexin A3 (ANXA3) is dysregulated and plays an important role in various
cancers. However, the role of ANXA3 in breast cancer is still unclear. Here, we observed that …

[HTML][HTML] Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer cells

T Wang, J Yuan, J Zhang, R Tian, W Ji, Y Zhou… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Overexpression of annexin A2 (Anxa2) is correlated with invasion and metastasis in breast
cancer cells. In this study, breast cancer patients with upregulated Anxa2 exhibited poor …

Annexin‐1 signals mitogen‐stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2

T Khau, SY Langenbach, M Schuliga… - The FASEB …, 2011 - Wiley Online Library
The role of the calcium‐and phospho‐lipid‐binding protein annexin I (ANXA1) in cell cycle
regulation has been investigated in estrogen receptor (ER)‐positive MCF‐7 and ER …

Annexin A1 in inflammation and breast cancer: a new axis in the tumor microenvironment

LA Moraes, PB Ampomah, LHK Lim - Cell adhesion & migration, 2018 - Taylor & Francis
Targeting inflammation in cancer has shown promise to improve and complement current
therapies. The tumor microenvironment plays an important role in cancer growth and …

Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment

LA Moraes, S Kar, SL Foo, T Gu, YQ Toh… - Scientific reports, 2017 - nature.com
Macrophages are potent immune cells with well-established roles in the response to stress,
injury, infection and inflammation. The classically activated macrophages (M1) are induced …

Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer

M Okano, K Kumamoto, M Saito… - Oncology …, 2015 - spandidos-publications.com
Abstract Annexin A1 (ANXA1) is a calcium-dependent phospholipid-linked protein, involved
in anti-inflammatory effects, regulation of cellular differentiation, proliferation and apoptosis …

ANXA4 activates JAK-STAT3 signaling by interacting with ANXA1 in basal-like breast cancer

L Li, R Zhang, Y Liu, G Zhang - DNA and Cell Biology, 2020 - liebertpub.com
Annexin A4 (encoded by the ANXA4 gene) is a calcium ion (Ca2+)-and phospholipid-
binding protein of the Annexin family. In this study, we checked the expression profile of …

Annexin A1 localization and its relevance to cancer

Z Boudhraa, B Bouchon, C Viallard, M D'Incan… - Clinical …, 2016 - portlandpress.com
Annexin A1 (ANXA1) is a Ca2+-regulated phospholipid-binding protein involved in various
cell processes. ANXA1 was initially widely studied in inflammation resolution, but its …